- Gerard Butler as Manny Rivera/El Tigre
- Lena Headey as Frida Suárez
- Martin Sheen as Grandpipi Rivera
- Emma Watson as Elsa Rivera
- Tom Kenny as Diego/Dr. Chipotle, Jr.
- Kelly Craig as Zoe Aves/Black Cuervo
- Jeremy Irons as Rodolfo Rivera (Flashbacks)
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